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Artículo

Cardiopatía isquémica

REC Interv Cardiol. 2020;1:15-21

Diferencias relacionadas con el sexo en pacientes con IAMCEST: análisis por puntuación de propensión

Gender-related differences among patients with STEMI: a propensity score analysis

Francesco Tomassinia,, Enrico Cerratoa,.,, Cristina Rolfoa, Matteo Biancob, Luca Lo Savioc, Alicia Quirósd,e, Mauro Echavarria-Pintof, Sara Giolittod, Emanuele Tizzanic, Antonella Corletoc, Giorgio Quadria, Rosario Tripodic, Davide Minnitig y Ferdinando Varbellaa

aDivisione di cardiologia inteventistica, Ospedale degli Infermi, Rivoli and Ospedale Universitario San Luigi Gonzaga, Orbassano, Turín, Italia

bDivisione di Cardiologia, Ospedale Universitario San Luigi Gonzaga, Orbassano, Turín, Italia

cDivisione di Cardiologia, Ospedale degli Infermi, Rivoli, Turín, Italia

dUnidad de Cardiología Intervencionista, Hospital Clínico San Carlos, Madrid, España

eDepartmento de Matemáticas, Universidad de León, España

fDepartamento de Cardiología, Hospital General ISSSTE, Querétaro, México

gDirezione Sanitaria, Ospedale degli Infermi, Rívoli, Italia


Ambos autores han contribuido por igual al artículo

Contenido relacionado

Mujer e IAMCEST: una responsabilidad compartida
Miren Telleria Arrieta

RESUMEN

Introducción y objetivos: El sexo femenino se considera un importante factor de riesgo de mortalidad en el infarto agudo de miocardio con elevación del segmento ST (IAMCEST) tratado con intervención coronaria percutánea primaria (ICPp).

Métodos: Se analizó a todos los pacientes consecutivos con IAMCEST tratados con ICPp dentro de las primeras 12 horas, y se compararon varones y mujeres. El objetivo principal fue la mortalidad a largo plazo en los supervivientes después del primer mes del alta, y el objetivo secundario fue la mortalidad a los 30 días.

Resultados: Desde marzo de 2006 hasta diciembre de 2016 se trató con ICPp a 1.981 pacientes, de los cuales 484 (24,4%) eran mujeres. En comparación con los varones, las mujeres tenían mayor edad (edad media 71,3 ± 11,6 frente a 62,9 ± 11,8 años, p < 0,001) y la frecuencia de fumadoras era más baja (26,7 frente a 72,7%; p < 0,001), mientras que era más alta la frecuencia de diabetes (28,0 frente a 22,3%; p < 0,002), hipertensión arterial (69.6 frente a 61,3%, p < 0,001) y shock al ingreso (13,2 frente a 9,0%; p = 0,006), y más largo el tiempo desde el comienzo de los síntomas hasta la intervención con balón (5,36 ± 3,97 fren- te a 4,47 ± 3,67 horas; p < 0,001). Además, la frecuencia de tratamiento con inhibidores de la glucoproteína IIb-IIIa (59,5 frente a 71,4%; p < 0,001) y stent (79,5 frente a 86,6%, p = 0,01) fue inferior. Tanto a los 30 días como a largo plazo (media 4,9 ± 3,2 años), el sexo femenino se asoció con una mortalidad más alta (8,9 frente a 4,0%, p < 0,001, y 23,8 frente a 18,4%, p = 0,01, res­pec­tivamente). Se seleccionaron 379 mujeres y 379 varones emparejados por puntuación de propensión. Se mantuvo la asociación entre sexo femenino y mayor mortalidad a los 30 días (9,5 frente a 5,5%; p = 0,039), pero no a largo plazo (25,6 frente a 21,4%; p = 0,170).

Conclusiones: En comparación con los varones, las mujeres con IAMCEST tratadas con ICPp tuvieron mayor mortalidad a los 30 días. Sin embargo, entre los supervivientes, la mortalidad a largo plazo fue similar. Aunque no puede descartarse el efecto de variables residuales de confusión, las diferencias en el pronóstico podrían explicarse en parte por diferencias biológicas relacionadas con el sexo.

Palabras clave: Infarto agudo de miocardio con elevación del segmento ST. Angioplastia primaria. Diferencias por sexo. Pronóstico.

ABSTRACT

Introduction and objectives: Female sex is believed to be a significant risk factor for mortality among patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary interventions (pPCI).

Methods: We collected data on all consecutive STEMI patients treated with pPCI within 12 hours and compared the males vs the females. The primary endpoint was long-term mortality one month after hospital discharge. The secondary endpoint was 30-days mortality.

Results: From March 2006 to December 2016, 1981 patients underwent pPCI at our hospital, 484 (24.4%) were females. Compared with men, women were older (mean age 71.3 ± 11.6 vs 62.9 ± 11.8 years, P < .001), less smokers (26.7% vs 72.7%; P < .001), more diabetic (28.0% vs 22.3%; P < .002), more hypertensive (69.6% vs 61.3%; P < .001), presented more often with shock at baseline (13.2% vs 9.0%; P = .006), had longer symptoms-to-balloon time frames (5.36 ± 3.97 vs 4.47 ± 3.67 hours; P < .001). Also, women were less likely to receive glycoprotein IIb-IIIa inhibitors (59.5% vs 71.4%; P < .001) and stents (79.5% vs 86.6%; P = .01). During the 30-day and long-term follow-up (mean 4.9 ± 3.2 years) the female sex was associated with a higher mortality rate (8.9% vs 4.0%, P < .001 and 23.8% vs 18.4%, P = .01, respectively). After propensity score matching, 379 men and 379 women were selected. Female sex continued to be associated with a higher death rate at 30 days (9.5% vs 5.5%; P = .039) but not in the long term among survivors (25.6% vs 21.4%; P = .170).

Conclusions: Compared to men, women with STEMI undergoing pPCI had higher 30-day mortality rates. However, among survivors, the long-term mortality rate was similar. Even if residual confounding cannot be ruled out, this difference in the outcomes may be partially explained by biological sex-related differences.

Keywords: ST-segment elevation myocardial infarction. Primary angioplasty. Sex differences. Outcomes.

Abreviaturas: IAMCEST: infarto agudo de miocardio con elevación del segmento ST. IPCp: intervención coronaria percutánea primaria.

INTRODUCCIÓN

La angioplastia primaria (ICPp) ha demostrado ser superior al tratamiento fibrinolítico en el manejo de pacientes con infarto agudo de miocardio con elevación del segmento ST (IAMCEST)1-3 y se ha convertido en el tratamiento preferido en este campo4. No obstante, sigue habiendo debate en torno a si hay diferencias pronósticas entre varones y mujeres. A pesar de que estudios recientes confirman que las mujeres tienen tasas de mortalidad más altas5, no está claro si estas diferencias se asocian a peores perfiles de riesgo o a una debilidad de género. De hecho, existen estudios que no han confirmado ninguna relación entre el género y la mortalidad en el IAMCEST, ni siquiera después de ajustar por edad y otros factores de riesgo6. De hecho, algunos estudios han descrito resultados de mortalidad a medio y largo plazo y diferencias en los criterios de inclusión (como por ejemplo todo el espectro del síndrome coronario agudo o solo el subgrupo IAMCEST) y en las estrategias terapéuticas (médicas o intervencionistas) que podrían explicar estos hallazgos contradictorios. El objetivo de este extenso registro de un único centro fue valorar posibles diferencias entre varones y mujeres en pacientes consecutivos con IAMCEST tratados con ICPp en cuanto a sus características clínicas, angiográficas, de la intervención y en los resultados clínicos a 30 días o a largo plazo.

MÉTODOS

Incluimos a todos los pacientes consecutivos ingresados en nuestro centro entre enero de 2006 y diciembre de 2016 con diagnóstico de IAMCEST y tratados con ICPp dentro de las 12horas siguientes al inicio de los síntomas. Se registraron las características basales (edad, sexo, carga de factores de riesgo cardiovascular, tiempo transcurrido desde el inicio de los síntomas hasta la intervención) y de la intervención (vaso diana, sitio y tipo de lesión, tratamiento farmacológico, tromboaspiración y tipo de stent). Todas las intervenciones se realizaron bajo los estándares actuales de la ICP y el tratamiento quedó a criterio del intervencionista. Se administró ácido acetilsalicílico, de manera rutinaria, a todos los pacientes (325 mg a su llegada y posteriormente 100mg/día indefinidamente) y un bolo intravenoso de heparina no fraccionada (5.000UI). El uso de bivalirudina (0,75 y 1,75mg/kg/hora al menos hasta el final de la intervención) o heparina no fraccionada (100 o 60U/kg si se empleó abciximab) o abciximab quedó a criterio del intervencionista. Cuando se utilizó, la infusión de abciximab se prolongó durante otras 12horas después de la intervención. Se administró una dosis de carga de clopidogrel (600 mg), prasugrel (60 mg) o ticagrelor (180 mg) antes o inmediatamente después de la ICP, salvo que los pacientes ya estuvieran a tratamiento de mantenimiento crónico. Después una dosis de mantenimiento de clopidogrel (75mg 1vez/día), prasugrel (10mg 1vez/día) o ticagrelor (90mg 2veces/día) durante 12meses siempre que fuera posible. Solo se repitió la revascularización ante la reaparición de síntomas o en presencia de isquemia confirmada asociada a la lesión tratada.

Los datos a 30 días de seguimiento de todos los pacientes estuvieron disponibles en la base de datos de nuestro centro. Transcurrido un mes, la información se recopiló mediante visitas ambulatorias, llamadas telefónicas o revisión de los historiales médicos para tener seguimientos más largos de cada paciente. Todos los datos se introdujeron en una base de datos dedicada.

Se compararon los objetivos de varones frente a mujeres antes y después del emparejamiento por puntuación de propensión. El objetivo primario fue la mortalidad a largo plazo después del alta hospitalaria. El objetivo secundario fue la tasa de mortalidad a 30 días y las hemorragias tipo ≥ 27 a 30 días y a largo plazo según los criterios del Bleeding Academic Research Consortium. Los eventos a largo plazo se evaluaron desde del día 31 después del alta y hasta el seguimiento más largo disponible. También se registró e informó sobre el índice de eficiencia de la intervención (definido como un flujo TIMI III [Thrombolysis in Myocardial Infarction] y una estenosis residual < 30%) y sobre la resolución del segmento ST > 50% 60–90 minutos después de la ICP.

Análisis estadístico

Las variables cuantitativas se expresaron como media ± desvia- ción estándar o mediana (Q1-Q3) según la normalidad de su distribución. Las cualitativas como frecuencias y porcentajes. Se emplearon las pruebas exacta de Fisher o X2 para las variables cualitativas y la prueba t de Student o U de Mann-Whitney para las variables cuantitativas, la más conveniente en cada caso. Los datos de supervivencia se representaron y analizaron empleando las curvas de Kaplan-Meier y el análisis de regresión de Cox. Todas las pruebas estadísticas fueron bilaterales. Los resultados se consideraron significativos con valores p < 0,05. Dadas las diferencias basales entre pacientes varones y mujeres y para reducir el sesgo de selección, empleamos el emparejamiento por puntuación de propensión. Utilizamos el modelo de regresión logística en función de las características basales y periprocedimiento. De este modo, pudimos definir valores p < 0,20 para incluir las variables seleccionadas en el modelo final. Las variables seleccionadas fueron: edad, tabaquismo, hipertensión, dislipemia, diabetes mellitus tipo 2, obesidad, insuficiencia renal crónica grave, shock al ingreso, reanimación cardiaca al ingreso, fracción de eyección < 35%, infarto de miocardio de la pared anterior, abordaje femoral, uso de bivalirudina, uso de inhibidores de la glucoproteína IIb-IIIa, angioplastia coronaria transluminal percutánea en el tronco común de la coronaria izquierda, uso de contrapulsación, trombectomía, uso de stents farmacoactivos y tiempo isquémico total. Empleando estas covariables, se calculó la pun­tuación de propensión de cada paciente. Cada mujer se emparejó en proporción 1:1 mediante la técnica del vecino más próximo con un varón del grupo de control con idéntica puntuación de propensión. La diferencia máxima (caliper) en las puntuaciones obtenidas en el emparejamiento por puntuación de propensión fue < 0,15. Las diferencias medias estandarizadas antes y después del emparejamiento y el equilibrio entre las 2 cohortes emparejadas se valoraron utilizando la prueba de T2 de Hotelling. Empleando esta técnica se obtuvieron 2 grupos comparables de 379 pacientes cada uno para el análisis final. Todas las diferencias medias estandarizadas después del emparejamiento estuvieron por debajo del 10%. La calibración se evaluó con la prueba de Hosmer- Lermeshow y la precisión usando el área bajo la curva (AUC) receiver operating characteristic (ROC). Los análisis estadísticos se realizaron con el paquete de software estadístico SPSS 21 (propiedad de IBM). Para el emparejamiento por puntuación de propensión se empleó la librería MatchIt del software estadístico R (versión 3.0.2).

RESULTADOS

Entre marzo de 2006 y diciembre de 2016, 484 (24,4%) de los 1.981 pacientes tratados con ICPp en nuestro hospital fueron mujeres (tabla 1). Comparadas con los varones, las mujeres eran más mayores (edad media, 71,3±11,6 frente a 62,9±11,8 años; p<0,001), menos fumadoras (26,7 frente al 72,7%; p<,001), más diabéticas (28,0 frente al 22,3%; p<0,002), e hipertensas (69,6 frente al 61,3%; p<0,001) y más propensas a sufrir shock cardiogénico durante el ingreso hospitalario (13,2 frente al 9,0%; p=0,006). También tenían tiempos síntoma-balón más largos (5,36 ± 3,97 frente a 4,47±3,67horas; p<0,001) y fracciones de eyección del ventrículo izquierdo más bajas (46,8±10% frente a 48,5±10%; p = 0,007). Además, tal y como muestra la tabla 2, las mujeres eran menos propensas a recibir tratamiento con in­hibidores de la glucoproteína IIb-IIIa (59,5 frente al 71,4%; p<0,001), dispositivos de tromboaspiración (48,3 frente al 58,0%, p<0,001) y stents (79,5 frente al 86,6%; p=0,01). Tanto la eficiencia de la intervención como la resolución del segmento ST fueron significativamente más bajas en la cohorte femenina (93,0 frente al 97,1%, p<0,001 y 60,0 frente al 65,8%, p=0,033, respectivamente y tabla 3).

Tabla 1. Características basales

    Crudas     Emparejadas    
  Total (n = 1.981) Mujer (n = 484; 24,4%) Varón (n = 1.497; 75,6%) p Mujer (n = 379) Varón (n = 379) p
Edad 65,0 ± 12,3 71,3 ± 11,6 62,9 ± 11,8 < 0,001 68,5 ± 11,9 69,2 ± 11,6 0,43
Edad > 80 años 262 (13,2) 134 (27,7) 128 (8,6) < 0,001 69 (18,2) 75 (19,8) 0,58
Diabetes mellitusa 469 (23,7) 135 (27,9) 334 (22,3) 0,002 63 (16,6) 74 (19,5) 0,29
Hipertensiónb 1.254 (63,3) 337 (69,6) 917 (61,3) 0,001 227 (59,9) 240 (63,3) 0,33
Dislipemiac 742 (37,5) 182 (37,6) 560 (37,4) 0,93 134 (35,4) 142 (37,5) 0,54
Obesidadd 307 (15,5) 113 (23,3) 194 (13,0) < 0,001 64 (16,9) 66 (17,4) 0,85
Insuficiencia renal crónicae 53 (2,7) 17 (3,5) 36 (2,4) 0,19 23 (6,1) 23 (6,1) 1,00
Tabaquismo (en la actualidad o en el pasado) 1.217 (61,4) 129 (26,7) 1.088 (72,7) < 0,001 129 (34,0) 129 (34,0) 1,00
Shock cardiogénico al ingreso 198 (10,0) 64 (13,2) 134 (9,0) 0,006 56 (14,8) 43 (11,3) 0,16
Intubación oral 116 (5,9) 31 (6,4) 85 (5,7) 0,56 26 (6,9) 23 (6,1) 0,66
Reanimación cardiaca al ingreso 21 (1,1) 8 (1,7) 13 (0,9) 0,14 7 (1,8) 8 (2,1) 0,79
Fracción de eyección del ventrículo izquierdo (%) 48,4 ± 10,0 46,8 ± 10,0 48,5 ± 10,0 0,007 47,5 ± 9,4 47,3 ± 9,6 0,83
Fracción de eyección del ventrículo izquierdo < 35% 202 (10,2) 69 (14,3) 133 (8,9) 0,001 43 (11,3) 44 (11,6) 0,91
Tiempo de isquemia total 4,7 ± 3,8 5,4 ± 4,0 4,5 ± 3,7 < 0,001 4,4 ± 3,7 4,6 ± 4,0 0,13
Infarto de miocardio en la pared anterior 877 (44,3) 217 (44,8) 660 (44,1) 0,82 165 (43,5) 165 (43,5) 1,00

a Definición según las guías de la American Heart Association.

b Presión sistémica arterial ≥ 140/90 mmHg.

c Niveles totales de colesterol ≥ 200 mg/dl; lipoproteínas de baja densidad ≥ 130 mg/dl; niveles de triacilglicerol ≥ 175 mg/dl.

d Índice de masa corporal > 30.

e Diálisis o creatinina sérica > 2 mg/dl.

Los datos expresan media ± desviación estándar o frecuencias (porcentajes).

Tabla 2. Características angiográficas y de la intervención

    Crudas     Emparejadas    
  Total (n = 1.981) Mujer (n = 484; 24,4%) Varón (n = 1.497; 75,6%) p Mujer (n = 379) Varón (n = 379) p
Enfermedad multivaso 1.055 (53,3) 259 (53,5) 796 (53,2) 0,90 194 (51,2) 195 (51,5) 0,94
Enfermedad del injerto 6 (0,3) 2 (0,4) 4 (0,3) 0,62 1 (0,3) 2 (0,5) 0,56
Abordaje radial 371 (18,7) 82 (16,9) 289 (19,3) 0,25 58 (15,3) 57 (15,0) 0,92
Uso de inhibidores GP IIb-IIIa 1.357 (68,5) 288 (59,5) 1.069 (71,4) < 0,001 251 (66,2) 242 (63,9) 0,49
Bivalirudina 210 (10,6) 61 (12,6) 149 (9,9) 0,12 35 (9,2) 45 (11,9) 0,24
ICP multivaso 93 (4,7) 25 (5,2) 68 (4,5) 0,57 20 (5,3) 18 (4,7) 0,74
ICP en tronco común de la coronaria izquierda 64 (3,2) 17 (3,5) 47 (3,1) 0,69 13 (3,4) 13 (3,4) 1,00
Contrapulsación aórtica 251 (12,7) 69 (14,3) 182 (12,2) 0,23 57 (15,0) 49 (12,9) 0,40
Tromboaspiración 1.102 (55,6) 234 (48,3) 868 (58,0) < 0,001 203 (53,6) 193 (50,9) 0,47
Implante de stent 1.682 (84,9) 385 (79,5) 1.297 (86,6) 0,01 314 (82,9) 318 (83,9) 0,58
Implante de stent farmacoactivo 832 (42,0) 194 (40,0) 658 (43,9) 0,09 148 (39,0) 152 (40,1) 0,77

GP: glucoproteína; ICP: intervención coronaria percutánea.

Los datos expresan media ± desviación estándar o frecuencias (porcentajes).

Tabla 3. Resultados

    Crudos     Emparejados    
  Total (n = 1.981) Mujer (n = 484; 24,4%) Varón (n = 1.497; 75,6%) p Mujer (n = 379) Varón (n = 379) p
Eficacia de la intervención 1.903 (96,1) 450 (93,0) 1.453 (97,1) < 0,001 342 (90,2) 358 (94,4) 0,039
Resolución del segmento ST > 50% 1.086 (64,4) 243 (60,0) 843 (65,8) 0,033 180 (47,5) 205 (54,1) 0,07
Hemorragias BARC tipo ≥ 2 a 30 días 27 (2,1) 22 (4,5) 21 (1,4) 0,002 16 (4,2) 6 (1,6) 0,007
Hemorragias BARC tipo ≥ 2 a largo plazo 41 (2,1) 21 (4,3) 20 (1,3) < 0,001 13 (3,4) 7 (1,8) 0,257
Tasa de mortalidad a 30 días 103 (5,2) 43 (8,9) 60 (4,0) < 0,001 36 (9,5) 21 (5,5) 0,039
Mortalidad global en el seguimiento a largo plazo 390 (19,7) 115 (23,8) 275 (18,4) 0,01 97 (25,6) 81 (21,4) 0,170

BARC: Bleeding Academic Research Consortium.

Los datos expresan frecuencias (porcentajes).

En el seguimiento a 30 días y a largo plazo (media 4,9 ± 3,2 años, completado en 1.634 pacientes, el 82,5%) el sexo femenino se asoció a una tasa de mortalidad más alta (del 8,9 frente al 4,0%, p < 0,001 y del 23,8 frente al 18,4%, p = 0,01, respectivamente) y a una incidencia de hemorragias mayores a los 30 días también más alta (del 4,5 frente al 1,4%; p = 0,002),

Después del emparejamiento por puntuación de propensión, se seleccionaron 379 varones y 379 mujeres. Las características basales y perioperatorias de las parejas emparejadas por puntuación de propensión fueron idénticas (tabla 1, tabla 2, figura 1, figura 2 y tabla 1 del material adicional y tabla 2 del material adicional). En esta cohorte, el sexo femenino siguió asociándose a una menor eficiencia de la intervención (94,4 frente al 90,2%; p = 0,039) y a una incidencia más alta de hemorragias mayores y muerte a los 30 días (9,5 frente al 5,5%, p = 0,039 and 4,2 frente al 1,6%, p = 0,007). En cambio, en la cohorte emparejada, no hubo diferencias significativas en la tasa de mortalidad a largo plazo entre los supervivientes (25,6 frente al 21,4%, p = 0,170, tabla 3; y prueba de log-rank p = 0,23, figura 3). El análisis de regresión múltiple de Cox reveló que la edad (hazard ratio [HR]=1,09 (1,06 – 1,12); p<0,001), el shock cardiogénico al ingreso (HR=6,82 (3,84 – 12,12); p<0,001), la fracción de eyección del ventrículo izquierdo < 35% (HR=1,98 (1,11 – 3,54); p = 0,022) y la eficacia de la intervención (HR=0,46 (0,23 – 0,89); p=0,022) resultaron predictores independientes, mientras que el sexo no lo fue. HR=0,68 (0,42 – 1,09); p=0,106) (tabla 4).

Tabla 4. Análisis de regresión múltiple

  HR (IC95%) p
Sexo femenino 0,68 (0,42 – 1,09) 0,106
Edad 1,09 (1,06 – 1,12) < 0,001
Shock cardiogénico en la presentación 6,82 (3,84 – 12,12) < 0,001
Fracción de eyección del ventrículo izquierdo < 35% 1,98 (1,11 – 3,54) 0,022
Eficacia de la intervención 0,46 (0,23 – 0,89) 0,022

HR: hazard ratio; IC95%: intervalo de confianza del 95%.

Modelo de riesgos proporcionales de Cox para la mortalidad global en el seguimiento a largo plazo.


Figura 1. Distribución de las puntuaciones de propensión. La puntuación de propensión va de 0 a 1 e incluye diferentes variables durante su estimación. Sirve para medir similitudes entre pacientes. Así, pacientes femeninos y masculinos emparejados muestran distribuciones similares de puntuaciones de propensión y un amplio rango cubriendo todos los tipos de pacientes. Las unidades de puntuación de propensión no emparejadas se aplican sobre extremos opuestos, como cabe esperar.

Figura 2. Distribución de las puntuaciones de propensión antes y después del emparejamiento.

Figura 3. Curva Kaplan-Meier para la mortalidad a largo plazo basada en el sexo. No se observa diferencia en la mortalidad a largo plazo entre pacientes femeninos y masculinos en la población emparejada.

El análisis de los objetivos principales se realizó en 2 periodos (2006-2010 y 2011-2016). No se observó ninguna diferencia entre los grupos (tabla 2 del material adicional).

DISCUSIÓN

Nuestro registro de un único centro reveló que en centros con alto volumen de ICP, las mujeres ingresadas con IAMCEST tratadas con ICPp tienen una tasa de mortalidad a 30 días y a largo plazo más alta que los varones; diferencias a 30 días que se mantienen incluso después de ajustar la puntuación de propensión.

Aunque la enfermedad cardiovascular sigue siendo la causa principal de muerte entre mujeres en todo el mundo, durante las últimas décadas se viene observando un descenso de la mortalidad cardiovascular que sigue siendo más alta en mujeres que en varones5. Hasta la fecha, esta diferencia se ha explicado por la prevalencia más alta de los factores de riesgo tradicionales (edad media más alta, hipertensión, diabetes e insuficiencia renal) en la cohorte femenina6. Además, las mujeres que sufren un infarto de miocardio suelen tener síntomas atípicos de presentación tales como disnea, fatiga, náusea/vómitos y dolor torácico atípico que pueden llevar a un diagnóstico y tratamiento tardíos8.

Otros factores asociados a una tasa más alta de mortalidad a tener en cuenta son las hemorragias y las complicaciones mecánicas, más frecuentes en mujeres que en varones9-11. Nuestro estudio confirmó todos estos datos: en nuestra población, las mujeres eran mucho más mayores, tenían más factores tradicionales de riesgo (salvo tabaquismo), tiempos isquémicos más largos y síntomas de presentación de mayor riesgo y, además, una incidencia más alta de hemorragias y complicaciones mecánicas.

Tras ajustar por puntuación de propensión, nuestro estudio confirmó que el sexo femenino se asoció independientemente a la mortalidad a 30 días pero no a largo plazo. Estos hallazgos son similares a los de un reciente y extenso metanálisis dirigido por Conrotto et al.2 de 98.778 pacientes (73.559 varones y 25.219 mujeres). Estos hallazgos se explican, al menos en parte, por la distinta fisiopatología de la enfermedad coronaria en las mujeres: la rotura de la superficie de la placa, la primera causa de las oclusiones coronarias en los varones sobreviene solo al 50% de las mujeres13. El porcentaje restante está representado por la erosión de la placa14, el espasmo coronario que provoca la formación de trombos15 y la disección espontánea de las coronarias16. En concreto la disección espontánea de las coronarias juega un papel importante en las mujeres más jóvenes (< 60 años) y se asocia a una incidencia alta de eventos cardiovasculares adversos mayores17. De ahí que estos hallazgos podrían explicar por qué, en nuestra población, las mujeres tenían un índice más bajo de tromboaspiración, uso de inhibidores de la glucoproteína IIb-IIIa e implante de stents. Sumado a las características clínicas todo esto explicaría el menor éxito de la intervención y resolución del segmento ST descritos en nuestro estudio. Estos factores, asociados a una incidencia mas alta de hemorragias, complicaciones mecánicas y otros factores psicológicos como la depresión, más prevalente en mujeres que en varones en la población general18,19, podrían ser los fenotipos de una mayor fragilidad de las mujeres y explicaría los peores resultados observados, al menos, a corto plazo. A largo plazo, otros factores como la menor incidencia de reestenosis del stent y la consiguiente menor necesidad de revascularización del vaso diana observados en las mujeres y descritos en algunos estudios20-23 explicarían los similares resultados observados en el análisis de emparejamiento por puntuación de propensión.

Limitaciones

Este estudio tiene importantes limitaciones; en primer lugar, aunque es un análisis retrospectivo, se alimenta de una base de datos prospectiva y dedicada con un análisis de emparejamiento por puntuación de propensión. En segundo lugar, los datos proceden de un único centro, lo cual limita su aplicabilidad. Por ejemplo, el uso de stents farmacoactivos fue menor de lo normal básicamente porque el marco temporal del estudio es amplio. En realidad, de 2006 a 2010 el porcentaje de stents farmacoactivos estuvo en torno al 15% mientras que, durante el segundo periodo (2011-2016), hubo un 65% de casos con implante de stent. Por último, debido al marco temporal fijado para la recopilación de datos, la mayoría de las intervenciones se realizaron por abordaje femoral, pero creemos que el abordaje radial podría haber reducido la incidencia de complicaciones hemorrágicas en el sitio de acceso. No obstante, necesitamos nuevos estudios dirigidos a la población femenina antes de poder validar esta hipótesis. No obstante, esta muestra probablemente sea representativa de una población IAMCEST no seleccionada tratada con ICPp en el mundo real.

CONCLUSIONES

En conclusión, tras ajustar por la puntuación de propensión en nuestra cohorte de pacientes de un único centro, aunque las mujeres IAMCEST tratadas con ICPp tienen una tasa de mortalidad a los 30 días más alta, los resultados a largo plazo son parecidos a los de los varones después del alta hospitalaria. Aunque no se pueden descartar factores de confusión residuales, esta diferencia en los resultados vendría explicada, en parte, por las diferencias de género biológicas.

CONFLICTO DE INTERESES

Ninguno de los autores ha declarado ningún conflicto de intereses relacionado con este artículo.

 

¿QUÉ SE SABE DEL TEMA?

  • Las mujeres tienen una mortalidad asociada al SCA más alta pero no hay consenso sobre si el sexo femenino es un factor de riesgo que condiciona peores resultados. Esto se debe a que muchos autores explican esta diferencia de género por el inicio atípico de los síntomas en las mujeres y por la menor recurrencia de intervenciones y angioplastias en el laboratorio de cateterismo realizadas en mujeres. Sin embargo, solo un pequeño número de estudios han descrito resultados de mortalidad a medio y largo plazo y todavía menos estudios tienen criterios claros de inclusión (como por ejemplo todo el espectro del síndrome coronario agudo o solo el subgrupo IAMCEST) o han descrito las estrategias de tratamiento utilizadas.

¿QUÉ APORTA DE NUEVO?

  • Nuestro extenso registro de un único centro reveló que en un centro con alto volumen de ICP, las mujeres que ingresan con IAMCEST y son tratadas con ICPp tienen un índice más alto de mortalidad a los 30 días y a largo plazo que los varones. Diferencia que se mantuvo incluso después de ajustar la puntuación de propensión para la mortalidad a 30 días, lo cual se explicaría por la mayor fragilidad del sexo femenino y, a su vez, los peores resultados descritos, al menos, a corto plazo.

MATERIAL ADICIONAL


 

BIBLIOGRAFÍA

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15. Kawana A, Takahashi J, Takagi Y, et al. Japanese Coronary Spasm Associ.ation. Gender differences in the clinical characteristics and outcomes of patients with vasospastic angina:a report from the Japanese Coronary Spasm Association. Circ J. 2013;77:1267-1274.

16. Vrints CJ. Spontaneous coronary artery dissection. Heart. 2010;96:801.808.

17. Tweet MS, Hayes SN, Pitta SR, et al. Clinical features, management, and prognosis of spontaneous coronary artery dissection. Circulation. 2012;126:579-588.

18. Yusuf S, Hawken S, Ounpuu S, et al. INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study):case-control study. Lancet. 2004;364:937-952.

19. Substance Abuse and Mental Health Services Administration. Results from the 2011 National Survey on Drug Use and Health:Mental Health Fin.dings. 2012. Disponible en: http://www.samhsa.gov/data/sites/default/files/2011MHFDT/2k11MHFR/Web/NSDUHmhfr2011.htm. Consultado 1 Jun 2019.

20. Alfonso F, Hernández R, Bañuelos C, et al. Initial results and long-term clinical and angiographic outcome of coronary stenting in women. Am J Cardiol. 2000;86:1380-1383.

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22. Presbitero P, Belli G, Zavalloni, et al. “Gender paradox“in outcome after percutaneous coronary intervention with paclitaxel eluting stents. Euro?Intervention. 2008;4:345-350.

23. Regueiro A, Fernández-Rodríguez D, Brugaletta S, et al. Sex-related Impact on Clinical Outcome of Everolimus-eluting Versus Bare-metal Stents in ST-segment Myocardial Infarction. Insights From the EXAMINATION Trial. Rev Esp Cardiol. 2015;68:382-389.

Autor para correspondencia: Interventional Cardiology, Infermi Hospital Rivoli and San Luigi Gonzaga Hospital, 10043 Orbassano, Turín, Italia.
Correo electrónico: enrico.cerrato@gmail.com (E. Cerrato).

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  • beforeRenderRawModule mod_custom (Innovacion Herramientas Estadísticas) (5.47KB) (51μs)
  • afterRenderRawModule mod_custom (Innovacion Herramientas Estadísticas) (928B) (109μs)
  • beforeRenderModule mod_custom (Innovacion Herramientas Estadísticas) (736B) (3μs)
  • afterRenderModule mod_custom (Innovacion Herramientas Estadísticas) (137.62KB) (4.65ms)
  • beforeRenderRawModule mod_custom (Article Herramientas Material Adicional) (3.53KB) (30μs)
  • afterRenderRawModule mod_custom (Article Herramientas Material Adicional) (944B) (89μs)
  • beforeRenderModule mod_custom (Article Herramientas Material Adicional) (736B) (3μs)
  • afterRenderModule mod_custom (Article Herramientas Material Adicional) (193.26KB) (5.91ms)
  • beforeRenderRawModule mod_menu (Contenido) (4.84KB) (726μs)
  • afterRenderRawModule mod_menu (Contenido) (18.63KB) (770μs)
  • beforeRenderModule mod_menu (Contenido) (704B) (5μs)
  • afterRenderModule mod_menu (Contenido) (3.08KB) (138μs)
  • beforeRenderRawModule mod_esmedicodisclaimer (esmedicodisclaimer esmedicodisclaimer) (2.36KB) (22μs)
  • afterRenderRawModule mod_esmedicodisclaimer (esmedicodisclaimer esmedicodisclaimer) (7.09KB) (284μs)
  • beforeRenderModule mod_esmedicodisclaimer (esmedicodisclaimer esmedicodisclaimer) (752B) (3μs)
  • afterRenderModule mod_esmedicodisclaimer (esmedicodisclaimer esmedicodisclaimer) (5.48KB) (145μs)
  • beforeRenderRawModule mod_menu (Publicar) (1.61KB) (136μs)
  • afterRenderRawModule mod_menu (Publicar) (29.84KB) (825μs)
  • beforeRenderModule mod_menu (Publicar) (704B) (3μs)
  • afterRenderModule mod_menu (Publicar) (3.33KB) (126μs)
  • beforeRenderRawModule mod_menu (Sobre nosotros) (160B) (111μs)
  • afterRenderRawModule mod_menu (Sobre nosotros) (22.34KB) (732μs)
  • beforeRenderModule mod_menu (Sobre nosotros) (720B) (4μs)
  • afterRenderModule mod_menu (Sobre nosotros) (3.2KB) (129μs)
  • beforeRenderRawModule mod_menu (Publicaciones Permanyer) (144B) (115μs)
  • afterRenderRawModule mod_menu (Publicaciones Permanyer) (10.24KB) (459μs)
  • beforeRenderModule mod_menu (Publicaciones Permanyer) (720B) (4μs)
  • afterRenderModule mod_menu (Publicaciones Permanyer) (2.89KB) (125μs)
  • beforeRenderRawModule mod_menu (Footer Final ES) (4.92KB) (847μs)
  • afterRenderRawModule mod_menu (Footer Final ES) (28.11KB) (796μs)
  • beforeRenderModule mod_menu (Footer Final ES) (720B) (4μs)
  • afterRenderModule mod_menu (Footer Final ES) (3.33KB) (138μs)
  • afterRender (1.03MB) (90.03ms)
  • 1 x afterRenderModule mod_custom (Lo más compartido) (578.67KB) (35.36%)
    448ms
    1 x afterRenderModule mod_custom (Lo más leído) (1.31MB) (28.93%)
    367ms
    1 x afterRender (1.03MB) (7.11%)
    90.03ms
    1 x afterRenderComponent com_content (263.13KB) (3.91%)
    49.52ms
    1 x Before Access::getAssetRules (id:8 name:com_content) (1.35MB) (3.2%)
    40.53ms
    1 x afterInitialise (3.53MB) (2.83%)
    35.91ms
    1 x afterRenderModule mod_custom (Article Herramientas Estadísticas) (738.55KB) (1.81%)
    22.97ms
    1 x beforeRenderRawModule mod_breadcrumbs (Breadcrumbs ES) (1.11MB) (1.44%)
    18.23ms
    1 x afterRoute (385.33KB) (1.2%)
    15.25ms
    1 x afterRenderModule mod_custom (Header Article) (547.98KB) (1.14%)
    14.45ms
    1 x afterRenderRawModule mod_dms3_refs (Article Herramientas Exportar) (95.51KB) (0.74%)
    9.34ms
    1 x afterRenderModule mod_custom (Article Herramientas Traducción) (276.55KB) (0.6%)
    7.60ms
    1 x Before Access::getAssetRules (id:1 name:root.1) (319.51KB) (0.59%)
    7.52ms
    1 x afterRenderModule mod_custom (Article Herramientas Compartir) (350.13KB) (0.59%)
    7.47ms
    1 x afterRenderModule mod_custom (Article - Referencia ) (324.97KB) (0.56%)
    7.09ms
    1 x afterRenderModule mod_custom (Article DOI activo) (258.55KB) (0.53%)
    6.69ms
    1 x afterRenderModule mod_custom (Debate Title) (421.07KB) (0.52%)
    6.59ms
    1 x afterRenderModule mod_custom (Article Translated Title) (1.47MB) (0.48%)
    6.10ms
    1 x afterRenderModule mod_custom (Article Herramientas Material Adicional) (193.26KB) (0.47%)
    5.91ms
    1 x afterDispatch (396.3KB) (0.45%)
    5.74ms
    1 x afterRenderModule mod_custom (Innovacion Herramientas Compartir) (218.51KB) (0.43%)
    5.44ms
    1 x afterRenderModule mod_custom (Article Related contents) (190.63KB) (0.42%)
    5.29ms
    1 x afterRenderModule mod_custom (Article Category) (230.75KB) (0.41%)
    5.23ms
    1 x afterRenderModule mod_custom (Article Authors) (169.41KB) (0.39%)
    4.92ms
    1 x afterRenderModule mod_custom (Foto Autor) (162.19KB) (0.38%)
    4.77ms
    1 x afterRenderModule mod_custom (Innovacion Herramientas Estadísticas) (137.62KB) (0.37%)
    4.65ms
    1 x afterRenderModule mod_custom (Article Subtitulo) (161.86KB) (0.36%)
    4.58ms
    1 x afterRenderModule mod_custom (Innovacion Herramientas Traducción) (151.14KB) (0.35%)
    4.40ms
    1 x afterRenderModule mod_custom (EMAIL Y TWITTER) (129.35KB) (0.33%)
    4.21ms
    1 x afterRenderModule mod_custom (Article Title) (150.18KB) (0.33%)
    4.20ms
    1 x afterRenderModule mod_custom (Separador) (128.77KB) (0.33%)
    4.19ms
    1 x afterRenderModule mod_custom (Article Herramientas Imprimir) (128.43KB) (0.33%)
    4.17ms
    1 x afterRenderModule mod_custom (Innovacion Herramientas Imprimir) (128.27KB) (0.33%)
    4.14ms
    1 x afterRenderModule mod_custom (Article Herramientas Descargar) (127.94KB) (0.32%)
    4.04ms
    1 x After Access::preloadPermissions (com_content) (987.52KB) (0.31%)
    3.91ms
    1 x afterLoad (74.89KB) (0.19%)
    2.45ms
    1 x beforeRenderRawModule mod_custom (Publicación de la Sociedad Española de Cardiología) (13.89KB) (0.17%)
    2.19ms
    1 x afterRenderRawModule mod_languages (Cambiar Idioma) (34.77KB) (0.12%)
    1.54ms
    1 x afterRenderRawModule mod_articles_good_search (Articles Good Search Total (Lateral)) (34.63KB) (0.1%)
    1.31ms
    1 x beforeRenderRawModule mod_custom (Separador) (2.04KB) (0.07%)
    945μs
    1 x afterRenderModule mod_custom (Home Concurso Hemodinamica) (6.23KB) (0.07%)
    896μs
    1 x afterRenderRawModule mod_breadcrumbs (Breadcrumbs ES) (13.98KB) (0.07%)
    895μs
    1 x After Access::preloadComponents (all components) (125.96KB) (0.07%)
    863μs
    1 x beforeRenderRawModule mod_menu (Footer Final ES) (4.92KB) (0.07%)
    847μs
    1 x afterRenderRawModule mod_menu (Publicar) (29.84KB) (0.07%)
    825μs
    1 x afterRenderRawModule mod_menu (Footer Final ES) (28.11KB) (0.06%)
    796μs
    1 x Before Access::preloadComponents (all components) (196.7KB) (0.06%)
    776μs
    1 x afterRenderRawModule mod_menu (Contenido) (18.63KB) (0.06%)
    770μs
    1 x afterRenderRawModule mod_menu (Sidebar Menú ES) (9.75KB) (0.06%)
    749μs
    1 x afterRenderRawModule mod_menu (Sobre nosotros) (22.34KB) (0.06%)
    732μs
    1 x beforeRenderRawModule mod_menu (Contenido) (4.84KB) (0.06%)
    726μs
    1 x afterRenderRawModule mod_menu (Sidebar - REC: Publications) (16.07KB) (0.04%)
    515μs
    1 x afterRenderRawModule mod_menu (Publicaciones Permanyer) (10.24KB) (0.04%)
    459μs
    1 x afterRenderRawModule mod_custom (Header Article) (4.19KB) (0.04%)
    445μs
    1 x beforeRenderComponent com_content (12.84KB) (0.03%)
    332μs
    1 x afterRenderModule mod_breadcrumbs (Breadcrumbs ES) (3.88KB) (0.03%)
    319μs
    1 x afterRenderRawModule mod_lightbox (Lightbox) (72.07KB) (0.02%)
    306μs
    1 x afterRenderRawModule mod_esmedicodisclaimer (esmedicodisclaimer esmedicodisclaimer) (7.09KB) (0.02%)
    284μs
    1 x afterRenderModule mod_articles_good_search (Articles Good Search Total (Lateral)) (10.48KB) (0.02%)
    255μs
    1 x beforeRenderRawModule mod_custom (Debate Title) (560B) (0.02%)
    239μs
    1 x beforeRenderRawModule mod_custom (Home Concurso Hemodinamica) (80B) (0.02%)
    223μs
    1 x beforeRenderRawModule mod_custom (Header Article) (2.04KB) (0.01%)
    185μs
    1 x afterRenderModule mod_dms3_refs (Article Herramientas Exportar) (3.23KB) (0.01%)
    163μs
    1 x afterRenderModule mod_esmedicodisclaimer (esmedicodisclaimer esmedicodisclaimer) (5.48KB) (0.01%)
    145μs
    1 x afterRenderModule mod_menu (Contenido) (3.08KB) (0.01%)
    138μs
    1 x afterRenderModule mod_menu (Footer Final ES) (3.33KB) (0.01%)
    138μs
    1 x beforeRenderRawModule mod_menu (Publicar) (1.61KB) (0.01%)
    136μs
    1 x afterRenderModule mod_languages (Cambiar Idioma) (3.97KB) (0.01%)
    135μs
    1 x afterRenderModule mod_custom (Article - Disponible Online) (2.67KB) (0.01%)
    134μs
    1 x afterRenderModule mod_custom (Publicación de la Sociedad Española de Cardiología) (2.81KB) (0.01%)
    134μs
    1 x afterRenderModule mod_lightbox (Lightbox) (4.45KB) (0.01%)
    132μs
    1 x afterRenderModule mod_menu (Sidebar Menú ES) (2.7KB) (0.01%)
    130μs
    1 x afterRenderRawModule mod_custom (Separador) (1.13KB) (0.01%)
    129μs
    1 x afterRenderModule mod_menu (Sobre nosotros) (3.2KB) (0.01%)
    129μs
    1 x afterRenderModule mod_menu (Publicar) (3.33KB) (0.01%)
    126μs
    1 x afterRenderModule mod_menu (Publicaciones Permanyer) (2.89KB) (0.01%)
    125μs
    1 x afterRenderModule mod_menu (Sidebar - REC: Publications) (3.23KB) (0.01%)
    122μs
    1 x afterRenderModule mod_custom (Factor de Impacto) (2.84KB) (0.01%)
    119μs
    1 x beforeRenderRawModule mod_menu (Publicaciones Permanyer) (144B) (0.01%)
    115μs
    1 x beforeRenderRawModule mod_menu (Sobre nosotros) (160B) (0.01%)
    111μs
    1 x afterRenderRawModule mod_custom (Innovacion Herramientas Estadísticas) (928B) (0.01%)
    109μs
    1 x beforeRenderRawModule mod_lightbox (Lightbox) (7.17KB) (0.01%)
    108μs
    1 x beforeRenderRawModule mod_languages (Cambiar Idioma) (5.38KB) (0.01%)
    103μs
    1 x afterRenderRawModule mod_custom (Publicación de la Sociedad Española de Cardiología) (1.09KB) (0.01%)
    98μs
    1 x After Access::getAssetRules (id:1571 name:com_content.article.253) (9.4KB) (0.01%)
    92μs
    1 x afterRenderRawModule mod_custom (Lo más compartido) (912B) (0.01%)
    92μs
    1 x afterRenderRawModule mod_custom (Article Herramientas Estadísticas) (928B) (0.01%)
    92μs
    1 x afterRenderRawModule mod_custom (Innovacion Herramientas Compartir) (928B) (0.01%)
    91μs
    1 x afterRenderRawModule mod_custom (Article Herramientas Compartir) (928B) (0.01%)
    89μs
    1 x afterRenderRawModule mod_custom (Innovacion Herramientas Imprimir) (8.91KB) (0.01%)
    89μs
    1 x afterRenderRawModule mod_custom (Article Herramientas Material Adicional) (944B) (0.01%)
    89μs
    1 x afterRenderRawModule mod_custom (EMAIL Y TWITTER) (1.02KB) (0.01%)
    87μs
    1 x afterRenderRawModule mod_custom (Article Herramientas Imprimir) (928B) (0.01%)
    85μs
    1 x afterRenderRawModule mod_custom (Article Herramientas Descargar) (992B) (0.01%)
    83μs
    1 x afterRenderRawModule mod_custom (Debate Title) (976B) (0.01%)
    82μs
    1 x afterRenderRawModule mod_custom (Innovacion Herramientas Traducción) (1.03KB) (0.01%)
    80μs
    1 x afterRenderRawModule mod_custom (Factor de Impacto) (976B) (0.01%)
    79μs
    1 x afterRenderRawModule mod_custom (Article Herramientas Traducción) (1.16KB) (0.01%)
    79μs
    1 x afterRenderRawModule mod_custom (Article Authors) (976B) (0.01%)
    78μs
    1 x afterRenderRawModule mod_custom (Article Subtitulo) (976B) (0.01%)
    78μs
    1 x afterRenderRawModule mod_custom (Article Related contents) (11.91KB) (0.01%)
    78μs
    1 x afterRenderRawModule mod_custom (Home Concurso Hemodinamica) (928B) (0.01%)
    78μs
    1 x afterRenderRawModule mod_custom (Article - Disponible Online) (3.48KB) (0.01%)
    77μs
    1 x afterRenderRawModule mod_custom (Article - Referencia ) (1.02KB) (0.01%)
    77μs
    1 x afterRenderRawModule mod_custom (Article Translated Title) (992B) (0.01%)
    77μs
    1 x afterRenderRawModule mod_custom (Article DOI activo) (1.02KB) (0.01%)
    76μs
    1 x afterRenderRawModule mod_custom (Foto Autor) (1.02KB) (0.01%)
    76μs
    1 x afterRenderRawModule mod_custom (Article Title) (976B) (0.01%)
    76μs
    1 x afterRenderRawModule mod_custom (Lo más leído) (912B) (0.01%)
    75μs
    1 x afterRenderRawModule mod_custom (Article Category) (1.02KB) (0.01%)
    75μs
    1 x Before Access::getAssetRules (id:1571 name:com_content.article.253) (66.8KB) (0%)
    54μs
    1 x beforeRenderRawModule mod_custom (Innovacion Herramientas Estadísticas) (5.47KB) (0%)
    51μs
    1 x beforeRenderRawModule mod_custom (Innovacion Herramientas Compartir) (5.86KB) (0%)
    37μs
    1 x beforeRenderRawModule mod_articles_good_search (Articles Good Search Total (Lateral)) (9.73KB) (0%)
    35μs
    1 x beforeRenderRawModule mod_custom (Innovacion Herramientas Imprimir) (1.48KB) (0%)
    33μs
    1 x beforeRenderRawModule mod_custom (Lo más compartido) (640B) (0%)
    32μs
    1 x beforeRenderRawModule mod_custom (Factor de Impacto) (13.19KB) (0%)
    31μs
    1 x beforeRenderRawModule mod_custom (EMAIL Y TWITTER) (1.41KB) (0%)
    31μs
    1 x beforeRenderRawModule mod_custom (Article Herramientas Estadísticas) (3.52KB) (0%)
    31μs
    1 x beforeRenderRawModule mod_custom (Article Herramientas Material Adicional) (3.53KB) (0%)
    30μs
    1 x beforeRenderRawModule mod_custom (Article Herramientas Compartir) (48B) (0%)
    28μs
    1 x beforeRenderRawModule mod_custom (Article Herramientas Imprimir) (1.52KB) (0%)
    27μs
    1 x beforeRenderRawModule mod_dms3_refs (Article Herramientas Exportar) (2.83KB) (0%)
    27μs
    1 x beforeRenderRawModule mod_custom (Innovacion Herramientas Traducción) (2.11KB) (0%)
    26μs
    1 x beforeRenderRawModule mod_custom (Article Herramientas Descargar) (1.45KB) (0%)
    24μs
    1 x beforeRenderRawModule mod_menu (Sidebar Menú ES) (768B) (0%)
    23μs
    1 x beforeRenderRawModule mod_esmedicodisclaimer (esmedicodisclaimer esmedicodisclaimer) (2.36KB) (0%)
    22μs
    1 x beforeRenderRawModule mod_custom (Article Authors) (1.94KB) (0%)
    22μs
    1 x beforeRenderRawModule mod_custom (Article Related contents) (1.14KB) (0%)
    22μs
    1 x beforeRenderRawModule mod_custom (Article Herramientas Traducción) (1.48KB) (0%)
    22μs
    1 x beforeRenderRawModule mod_custom (Article DOI activo) (1.22KB) (0%)
    21μs
    1 x beforeRenderRawModule mod_custom (Article Title) (1.44KB) (0%)
    21μs
    1 x beforeRenderRawModule mod_custom (Article - Disponible Online) (1.98KB) (0%)
    21μs
    1 x beforeRenderRawModule mod_custom (Article - Referencia ) (1.61KB) (0%)
    21μs
    1 x beforeRenderRawModule mod_custom (Foto Autor) (1.69KB) (0%)
    21μs
    1 x beforeRenderRawModule mod_menu (Sidebar - REC: Publications) (1.61KB) (0%)
    21μs
    1 x beforeRenderRawModule mod_custom (Article Subtitulo) (1.38KB) (0%)
    20μs
    1 x beforeRenderRawModule mod_custom (Article Translated Title) (1.11KB) (0%)
    20μs
    1 x beforeRenderRawModule mod_custom (Lo más leído) (2.39KB) (0%)
    18μs
    1 x beforeRenderRawModule mod_custom (Article Category) (832B) (0%)
    17μs
    1 x After Access::getAssetRules (id:1 name:root.1) (7.41KB) (0%)
    16μs
    1 x Before Access::preloadPermissions (com_content) (4.16KB) (0%)
    12μs
    1 x After Access::getAssetRules (id:8 name:com_content) (1.59KB) (0%)
    8μs
    1 x beforeRenderModule mod_dms3_refs (Article Herramientas Exportar) (736B) (0%)
    8μs
    1 x beforeRenderModule mod_menu (Contenido) (704B) (0%)
    5μs
    1 x beforeRenderModule mod_custom (Header Article) (720B) (0%)
    4μs
    1 x beforeRenderModule mod_lightbox (Lightbox) (720B) (0%)
    4μs
    1 x beforeRenderModule mod_languages (Cambiar Idioma) (704B) (0%)
    4μs
    1 x beforeRenderModule mod_articles_good_search (Articles Good Search Total (Lateral)) (752B) (0%)
    4μs
    1 x beforeRenderModule mod_menu (Sidebar Menú ES) (720B) (0%)
    4μs
    1 x beforeRenderModule mod_menu (Sidebar - REC: Publications) (736B) (0%)
    4μs
    1 x beforeRenderModule mod_custom (Separador) (720B) (0%)
    4μs
    1 x beforeRenderModule mod_menu (Sobre nosotros) (720B) (0%)
    4μs
    1 x beforeRenderModule mod_menu (Publicaciones Permanyer) (720B) (0%)
    4μs
    1 x beforeRenderModule mod_breadcrumbs (Breadcrumbs ES) (704B) (0%)
    4μs
    1 x beforeRenderModule mod_menu (Footer Final ES) (720B) (0%)
    4μs
    1 x beforeRenderModule mod_custom (Article DOI activo) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Category) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Foto Autor) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Title) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Translated Title) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Related contents) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Publicación de la Sociedad Española de Cardiología) (752B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Home Concurso Hemodinamica) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Lo más compartido) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Herramientas Traducción) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Innovacion Herramientas Traducción) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Herramientas Imprimir) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Innovacion Herramientas Imprimir) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Innovacion Herramientas Compartir) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_menu (Publicar) (704B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Debate Title) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article - Referencia ) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Authors) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Factor de Impacto) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Herramientas Descargar) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (EMAIL Y TWITTER) (720B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Herramientas Compartir) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Herramientas Estadísticas) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Innovacion Herramientas Estadísticas) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article Herramientas Material Adicional) (736B) (0%)
    3μs
    1 x beforeRenderModule mod_esmedicodisclaimer (esmedicodisclaimer esmedicodisclaimer) (752B) (0%)
    3μs
    1 x beforeRenderModule mod_custom (Article - Disponible Online) (736B) (0%)
    2μs
    1 x beforeRenderModule mod_custom (Article Subtitulo) (720B) (0%)
    2μs
    1 x beforeRenderModule mod_custom (Lo más leído) (720B) (0%)
    2μs
97 statements were executed, 25 of which were duplicates, 72 unique815ms2.07MB
  • SELECT @@SESSION.sql_mode;125μs1.57KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:308Copy
  • SELECT `data` FROM `yzfp0_session` WHERE `session_id` = ?170μs1.63KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:250Copy
  • SELECT `session_id` FROM `yzfp0_session` WHERE `session_id` = :session_id LIMIT 1150μs1.63KBParams/libraries/src/Session/MetadataManager.php:187Copy
  • UPDATE `yzfp0_session` SET `guest` = :guest , `time` = :time , `userid` = :user_id , `username` = :username , `client_id` = :client_id WHERE `session_id` = :session_id157μs992BParams/libraries/src/Session/MetadataManager.php:316Copy
  • SELECT `extension_id` AS `id`,`element` AS `option`,`params`,`enabled` FROM `yzfp0_extensions` WHERE `type` = 'component' AND `state` = 0 AND `enabled` = 1322μs2.31KB/libraries/src/Component/ComponentHelper.php:399Copy
  • SELECT `id`,`rules` FROM `yzfp0_viewlevels`147μs976B/libraries/src/Access/Access.php:955Copy
  • SELECT `b`.`id` FROM `yzfp0_usergroups` AS `a` LEFT JOIN `yzfp0_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt` WHERE `a`.`id` = :guest164μs1.64KBParams/libraries/src/Access/Access.php:868Copy
  • SELECT `folder` AS `type`,`element` AS `name`,`params` AS `params`,`extension_id` AS `id` FROM `yzfp0_extensions` WHERE `enabled` = 1 AND `type` = 'plugin' AND `state` IN (0,1) AND `access` IN (:preparedArray1,:preparedArray2) ORDER BY `ordering`895μs21.8KBParams/libraries/src/Plugin/PluginHelper.php:294Copy
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  • SELECT `m`.`id`,`m`.`menutype`,`m`.`title`,`m`.`alias`,`m`.`note`,`m`.`link`,`m`.`type`,`m`.`level`,`m`.`language`,`m`.`browserNav`,`m`.`access`,`m`.`params`,`m`.`home`,`m`.`img`,`m`.`template_style_id`,`m`.`component_id`,`m`.`parent_id`,`m`.`path` AS `route`,`e`.`element` AS `component` FROM `yzfp0_menu` AS `m` LEFT JOIN `yzfp0_extensions` AS `e` ON `m`.`component_id` = `e`.`extension_id` WHERE ( (`m`.`published` = 1 AND `m`.`parent_id` > 0 AND `m`.`client_id` = 0) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :currentDate1)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :currentDate2) ORDER BY `m`.`lft`1.26ms200.55KBParams/libraries/src/Menu/SiteMenu.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `yzfp0_categories` AS `s` INNER JOIN `yzfp0_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray1,:preparedArray2)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`357μs5.17KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `id` FROM `yzfp0_content` WHERE `alias` = :alias AND `catid` = :catid203μs1.65KBParams/components/com_content/src/Service/Router.php:263Copy
  • SELECT `id`,`home`,`template`,`s`.`params`,`inheritable`,`parent` FROM `yzfp0_template_styles` AS `s` LEFT JOIN `yzfp0_extensions` AS `e` ON `e`.`element` = `s`.`template` AND `e`.`type` = 'template' AND `e`.`client_id` = `s`.`client_id` WHERE `s`.`client_id` = 0 AND `e`.`enabled` = 1298μs1.55KB/administrator/components/com_templates/src/Model/StyleModel.php:775Copy
  • SELECT s.id, s.template, s.home, s.title AS long_title, s.params FROM yzfp0_template_styles AS s WHERE s.client_id = 0 AND s.template = 'g5_helium' ORDER BY s.id209μs1.48KB/libraries/gantry5/src/classes/Gantry/Joomla/StyleHelper.php:69Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `yzfp0_assets` WHERE `name` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40,:preparedArray41,:preparedArray42,:preparedArray43,:preparedArray44,:preparedArray45,:preparedArray46)472μs8.12KBParams/libraries/src/Access/Access.php:357Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `yzfp0_assets` WHERE `name` LIKE :asset OR `name` = :extension OR `parent_id` = 02.69ms96.3KBParams/libraries/src/Access/Access.php:301Copy
  • SHOW FULL COLUMNS FROM `yzfp0_content`307μs2.39KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:587Copy
  • UPDATE `yzfp0_content` SET `hits` = (`hits` + 1) WHERE `id` = '253'586μs48B/libraries/src/Table/Table.php:1348Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `yzfp0_content` AS `a` INNER JOIN `yzfp0_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `yzfp0_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `yzfp0_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `yzfp0_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `yzfp0_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)1.28ms96.69KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `yzfp0_categories` AS `s` INNER JOIN `yzfp0_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`402μs5.23KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `yzfp0_contentitem_tag_map` AS `m` INNER JOIN `yzfp0_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2)360μs5.23KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SHOW FULL COLUMNS FROM `yzfp0_users`286μs2.2KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:587Copy
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  • SELECT `g`.`id`,`g`.`title` FROM `yzfp0_usergroups` AS `g` INNER JOIN `yzfp0_user_usergroup_map` AS `m` ON `m`.`group_id` = `g`.`id` WHERE `m`.`user_id` = :muserid165μs1.68KBParams/libraries/src/Table/User.php:134Copy
  • SELECT * FROM `yzfp0_users` WHERE `id` = :userid157μs4.41KBParams/libraries/src/Table/User.php:106Copy
  • SELECT `g`.`id`,`g`.`title` FROM `yzfp0_usergroups` AS `g` INNER JOIN `yzfp0_user_usergroup_map` AS `m` ON `m`.`group_id` = `g`.`id` WHERE `m`.`user_id` = :muserid128μs1.68KBParams/libraries/src/Table/User.php:134Copy
  • SELECT `b`.`id` FROM `yzfp0_user_usergroup_map` AS `map` LEFT JOIN `yzfp0_usergroups` AS `a` ON `a`.`id` = `map`.`group_id` LEFT JOIN `yzfp0_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt` WHERE `map`.`user_id` = :userId146μs1.64KBParams/libraries/src/Access/Access.php:868Copy
  • SELECT r.* FROM yzfp0_rereplacer AS r WHERE r.published = 1 AND (r.area = 'articles' OR r.params LIKE '%\"use_xml\":\"1\"%') ORDER BY r.ordering, r.id270μs2.11KB/plugins/system/rereplacer/src/Items.php:97Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `yzfp0_categories` AS `s` INNER JOIN `yzfp0_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`299μs5.23KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM yzfp0_fields AS a LEFT JOIN `yzfp0_languages` AS l ON l.lang_code = a.language LEFT JOIN yzfp0_users AS uc ON uc.id=a.checked_out LEFT JOIN yzfp0_viewlevels AS ag ON ag.id = a.access LEFT JOIN yzfp0_users AS ua ON ua.id = a.created_user_id LEFT JOIN yzfp0_fields_groups AS g ON g.id = a.group_id LEFT JOIN `yzfp0_fields_categories` AS fc ON fc.field_id = a.id WHERE ( (`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray8,:preparedArray9) ORDER BY a.ordering ASC1.28ms54.94KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:164Copy
  • SELECT `field_id`,`value` FROM `yzfp0_fields_values` WHERE `field_id` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40,:preparedArray41,:preparedArray42,:preparedArray43,:preparedArray44,:preparedArray45,:preparedArray46,:preparedArray47,:preparedArray48,:preparedArray49) AND `item_id` = :itemid1.01ms7.77KBParams/administrator/components/com_fields/src/Model/FieldModel.php:747Copy
  • SELECT a.id,a.asset_id,a.title,a.alias,a.introtext,a.fulltext,a.state,a.catid,a.created,a.created_by,a.created_by_alias,CASE WHEN a.modified = '0000-00-00 00:00:00' THEN a.created ELSE a.modified END as modified,a.modified_by,a.checked_out,a.checked_out_time,a.publish_up,a.publish_down,a.images,a.urls,a.attribs,a.version,a.ordering,a.metakey,a.metadesc,a.access,a.hits,a.metadata,a.featured,a.language,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`lft` AS `category_lft`,`c`.`lft` AS `category_ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,ROUND(v.rating_sum / v.rating_count, 0) AS rating,`v`.`rating_count` AS `rating_count` FROM `yzfp0_content` AS `a` INNER JOIN `yzfp0_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `yzfp0_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `yzfp0_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `yzfp0_content_rating` AS `v` ON `v`.`content_id` = `a`.`id` WHERE `a`.`id` = 215 AND `c`.`published` > 0 AND (`a`.`state` = 1 AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= '2024-11-24 18:12:59') AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` = '0000-00-00 00:00:00' OR `a`.`publish_down` > '2024-11-24 18:12:59'))658μs106.44KB/libraries/regularlabs/src/Article.php:94Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `yzfp0_categories` AS `s` INNER JOIN `yzfp0_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`354μs5.23KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `yzfp0_content` AS `a` INNER JOIN `yzfp0_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `yzfp0_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `yzfp0_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `yzfp0_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `yzfp0_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)538μs96.73KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
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  • SELECT c.id FROM yzfp0_content AS c LEFT JOIN yzfp0_fields_values AS f1 ON c.id = f1.item_id AND f1.field_id = (SELECT id FROM yzfp0_fields WHERE name = "orden-nuevo") LEFT JOIN yzfp0_fields_values AS f2 ON c.id = f2.item_id AND f2.field_id = (SELECT id FROM yzfp0_fields WHERE name = "dms3-volumen") LEFT JOIN yzfp0_fields_values AS f3 ON c.id = f3.item_id AND f3.field_id = (SELECT id FROM yzfp0_fields WHERE name = "dms3-numero") WHERE c.language = 'es-ES' AND f1.value = '2' AND f2.value = '100' AND f3.value = '1' LIMIT 18.85ms856B/plugins/content/dms3articlenavigation/dms3articlenavigation.php:168Copy
  • SELECT c.id FROM yzfp0_content AS c LEFT JOIN yzfp0_fields_values AS f1 ON c.id = f1.item_id AND f1.field_id = (SELECT id FROM yzfp0_fields WHERE name = "orden-nuevo") LEFT JOIN yzfp0_fields_values AS f2 ON c.id = f2.item_id AND f2.field_id = (SELECT id FROM yzfp0_fields WHERE name = "dms3-volumen") LEFT JOIN yzfp0_fields_values AS f3 ON c.id = f3.item_id AND f3.field_id = (SELECT id FROM yzfp0_fields WHERE name = "dms3-numero") WHERE c.language = 'es-ES' AND f1.value = '0' AND f2.value = '100' AND f3.value = '1' LIMIT 11.56ms840B/plugins/content/dms3articlenavigation/dms3articlenavigation.php:168Copy
  • SELECT `catid`,`alias`,`language` FROM `yzfp0_content` WHERE `id` = '1103'125μs976B/plugins/content/dms3articlenavigation/dms3articlenavigation.php:227Copy
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  • SELECT `alias` FROM `yzfp0_content` WHERE `id` = :id109μs1.63KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid` FROM `yzfp0_content` AS `c` INNER JOIN `yzfp0_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `yzfp0_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `yzfp0_content` AS `c2` ON `a2`.`id` = `c2`.`id` INNER JOIN `yzfp0_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2 WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'es-ES' AND (c2.publish_up IS NULL OR c2.publish_up <= '2024-11-24 18:12:59') AND (c2.publish_down IS NULL OR c2.publish_down >= '2024-11-24 18:12:59') AND c2.state = 1342μs1.8KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `yzfp0_modules` AS `m` LEFT JOIN `yzfp0_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `yzfp0_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) AND `m`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY `m`.`position`,`m`.`ordering`1.76ms180.16KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
  • SELECT `a`.`menutype`,`a`.`title` FROM `yzfp0_menu_types` AS `a` WHERE `a`.`client_id` = 0241μs1.31KB/libraries/gantry5/src/classes/Gantry/Framework/Menu.php:138Copy
  • SELECT m.id, m.alias, m.path AS route, m.level, m.parent_id FROM yzfp0_menu AS m WHERE m.menutype = 'menu-es-new' AND m.parent_id > 0 AND m.client_id = 0 AND m.published >= 0 ORDER BY m.lft355μs1.92KB/libraries/gantry5/src/classes/Gantry/Framework/Menu.php:791Copy
  • SHOW FULL COLUMNS FROM `yzfp0_content`307μs2.39KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:587Copy
  • SELECT `article`.`id` AS `article.id`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[779] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` = 253 LIMIT 1158μs912B/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT category.id,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[263] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getUnpublishedCategoryIds\n[668] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_categories` AS `category` LEFT JOIN `yzfp0_categories` AS `parent` ON `category`.`parent_id` = `parent`.`id` WHERE `category`.`extension` = 'com_content' AND (category.published IN (0,-1,-2) OR parent.published IN (0,-1,-2)) GROUP BY category.id255μs896B/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[840] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getArticleIdsByFilters\n[324] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE ((`article`.`state` = 1 AND (`article`.`publish_up` IS NULL OR `article`.`publish_up` <= '2024-11-24 18:12:59') AND (`article`.`publish_down` IS NULL OR `article`.`publish_down` = '0000-00-00 00:00:00' OR `article`.`publish_down` > '2024-11-24 18:12:59')) AND article.access IN (1,5) AND article.language IN ('es-ES','*')) AND `article`.`id` = 253182μs912B/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,`article`.`catid` AS `article.catid`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[846] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` = 253 ORDER BY `article`.`title` IS NULL, CAST(`article`.`title` AS CHAR(1)) = '', CAST(`article`.`title` AS CHAR(10)) = '0000-00-00', CAST(`article`.`title` AS SIGNED INTEGER) = 0, CAST(`article`.`title` AS SIGNED INTEGER) ASC, `article`.`title` ASC LIMIT 1159μs976B/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `yzfp0_contentitem_tag_map` AS `m` INNER JOIN `yzfp0_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2)359μs5.23KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `yzfp0_contentitem_tag_map` AS `m` INNER JOIN `yzfp0_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2)411μs5.23KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT `alias` FROM `yzfp0_content` WHERE `id` = :id152μs1.63KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `yzfp0_content` WHERE `id` = :id110μs1.63KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT field.name,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[804] RegularLabs.Plugin.System.ArticlesAnywhere.DataGroups.Field.getFieldNames\n[799] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_fields` AS `field` WHERE field.context = 'com_content.article'258μs34.13KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,`article`.`catid` AS `article.catid`,`article`.`language` AS `article.language`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[779] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` = 253 LIMIT 1137μs1KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,`article`.`title` AS `article.title`,`article`.`catid` AS `article.catid`,`article`.`language` AS `article.language`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[846] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` = 253 ORDER BY `article`.`title` IS NULL, CAST(`article`.`title` AS CHAR(1)) = '', CAST(`article`.`title` AS CHAR(10)) = '0000-00-00', CAST(`article`.`title` AS SIGNED INTEGER) = 0, CAST(`article`.`title` AS SIGNED INTEGER) ASC, `article`.`title` ASC LIMIT 1147μs1.06KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,`article`.`catid` AS `article.catid`,`article`.`language` AS `article.language`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[846] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` = 253 ORDER BY `article`.`title` IS NULL, CAST(`article`.`title` AS CHAR(1)) = '', CAST(`article`.`title` AS CHAR(10)) = '0000-00-00', CAST(`article`.`title` AS SIGNED INTEGER) = 0, CAST(`article`.`title` AS SIGNED INTEGER) ASC, `article`.`title` ASC LIMIT 1181μs1KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,`article`.`catid` AS `article.catid`,`category`.`id` AS `category.id`,`category`.`title` AS `category.title`,`article`.`language` AS `article.language`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[846] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` LEFT JOIN `yzfp0_categories` AS `category` ON `category`.`id` = `article`.`catid` WHERE `article`.`id` = 253 ORDER BY `article`.`title` IS NULL, CAST(`article`.`title` AS CHAR(1)) = '', CAST(`article`.`title` AS CHAR(10)) = '0000-00-00', CAST(`article`.`title` AS SIGNED INTEGER) = 0, CAST(`article`.`title` AS SIGNED INTEGER) ASC, `article`.`title` ASC LIMIT 1237μs1.13KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `yzfp0_contentitem_tag_map` AS `m` INNER JOIN `yzfp0_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2)438μs5.23KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `yzfp0_contentitem_tag_map` AS `m` INNER JOIN `yzfp0_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2)368μs13.23KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT `c2`.`language`,`c2`.`id` FROM `yzfp0_menu` AS `c` INNER JOIN `yzfp0_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `yzfp0_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `yzfp0_menu` AS `c2` ON `a2`.`id` = `c2`.`id` WHERE `c`.`id` = :id297μs1.72KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT * FROM `yzfp0_fields` AS `a` WHERE a.state IN (:preparedArray1,:preparedArray2) AND `a`.`context` = 'com_content.article'415μs54.11KBParams/plugins/system/articlesanywhere/src/DataGroups/Helpers/Fields.php:105Copy
  • SELECT *,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[590] RegularLabs.Plugin.System.ArticlesAnywhere.DataGroups.Field.getFieldFromDatabase\n[770] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_fields` AS `field` WHERE field.context = 'com_content.article' AND `field`.`name` = 'dms3-content-type'273μs4.09KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT value.item_id,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[443] RegularLabs.Plugin.System.ArticlesAnywhere.DataGroups.Field.getWhere\n[670] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_fields_values` AS `value` INNER JOIN `yzfp0_fields` AS `field` ON `field`.`id` = `value`.`field_id` WHERE `field`.`name` = 'dms3-content-type' AND `field`.`state` = 1 AND `field`.`context` = 'com_content.article' AND `value`.`value` = 'dms3_article'2.26ms436.88KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[727] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getArticleIdsByFilters\n[324] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` LEFT JOIN `yzfp0_fields` AS `field-dms3-content-type` ON `field-dms3-content-type`.`name` = 'dms3-content-type' AND `field-dms3-content-type`.`state` = 1 AND `field-dms3-content-type`.`context` = 'com_content.article' LEFT JOIN `yzfp0_fields_values` AS `field_value-dms3-content-type` ON `field_value-dms3-content-type`.`field_id` = `field-dms3-content-type`.`id` AND `field_value-dms3-content-type`.`item_id` = article.id WHERE ((`article`.`state` = 1 AND (`article`.`publish_up` IS NULL OR `article`.`publish_up` <= '2024-11-24 18:12:59') AND (`article`.`publish_down` IS NULL OR `article`.`publish_down` = '0000-00-00 00:00:00' OR `article`.`publish_down` > '2024-11-24 18:12:59')) AND article.access IN (1,5) AND article.language IN ('es-ES','*')) AND article.id IN 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  • SELECT `article`.`id` AS `article.id`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[757] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getArticleIdsByArticleIds\n[301] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` IN (1259,3,4,5,6,7,8,9,10,11,12,13,15,16,21,22,23,31,36,37,1288,1287,1286,1279,1278,1277,1276,1303,261,1315,260,753,1053,1272,242,241,240,239,230,229,228,227,226,225,214,213,212,211,210,1309,1310,1311,1314,1322,1323,1324,1331,1332,1335,1298,1297,1293,1292,1291,1290,1265,1264,1263,1262,1258,1257,1256,1255,1251,1244,1234,1230,1229,1227,1224,1223,1222,1220,1214,1212,1211,1210,1209,1208,1207,1206,1205,1204,1199,1195,1190,1185,1184,1179,1178,1174,1165,1164,1163,1159,1158,1157,1156,1154,1153,1152,1151,1149,1148,1147,1144,1139,1138,1137,1135,1123,1119,1118,1117,1116,1115,1113,1107,1105,1104,1098,1097,1096,1095,1094,1091,1084,1083,1082,1081,1076,1075,1074,1073,1072,1066,1065,1060,1057,1052,1047,1046,1045,1044,1043,1037,1033,1032,1031,1027,1025,1024,1022,1020,1019,1016,1012,1010,1008,1007,1004,1003,1000,995,992,984,979,977,976,975,974,973,972,971,970,969,968,967,966,965,964,963,962,961,949,938,935,934,933,927,926,925,923,919,918,917,916,914,908,906,905,904,903,899,897,892,890,884,883,882,881,880,878,877,873,862,861,860,857,856,852,850,849,848,838,837,836,835,833,831,830,829,828,823,821,805,804,803,801,800,799,798,797,793,792,791,790,789,780,779,778,767,55,755,754,752,751,750,749,748,747,746,744,743,742,741,737,735,734,731,729,723,719,718,717,712,711,710,708,707,706,704,689,686,685,683,676,675,672,671,666,665,664,649,648,647,643,642,637,634,633,629,628,622,621,614,613,608,605,604,603,602,561,560,556,547,543,542,540,535,528,520,519,518,509,508,506,505,503,502,484,483,482,479,477,476,460,459,458,457,455,454,453,452,450,433,432,431,430,429,423,422,421,420,413,412,411,410,403,402,401,399,385,384,383,382,381,376,375,374,373,372,371,370,369,361,360,359,358,356,354,353,352,351,350,276,275,274,273,272,271,270,264,54,59,60,253,345,344,339,333,332,331,322,321,320,319,318,317,316,315,314,308,307,305,300,299,298,287,286,285,587,584,572,183,182,181,178,177,175,171,170,169,164,163,161,1261,847,846,1317,1260,663,607,570,569,567,566,565,564,563,562,493,492,491,438,437,436,435,434,283,258,256,255,254,184,174,173,172,166,165,160,159,158,149,148,147,139,138,137,136,134,133,132,131,130,124,121,119,116,115,113,2586,2589,2590,2591,2592,2594,2595,2596,2598,2599,2600,2605,2611) ORDER BY `article`.`hits` IS NULL, CAST(`article`.`hits` AS CHAR(1)) = '', CAST(`article`.`hits` AS CHAR(10)) = '0000-00-00', CAST(`article`.`hits` AS SIGNED INTEGER) = 0, CAST(`article`.`hits` AS SIGNED INTEGER) DESC, `article`.`hits` DESC LIMIT 31.97ms944B/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,`article`.`title` AS `article.title`,`article`.`alias` AS `article.alias`,`article`.`catid` AS `article.catid`,`article`.`language` AS `article.language`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[765] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` IN (320,344,339) ORDER BY FIELD(article.id,320,344,339)226μs1.16KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `yzfp0_categories` AS `s` INNER JOIN `yzfp0_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`475μs5.22KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `yzfp0_categories` AS `s` INNER JOIN `yzfp0_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`410μs5.23KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `alias` FROM `yzfp0_content` WHERE `id` = :id179μs1.63KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `yzfp0_content` WHERE `id` = :id173μs1.63KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `article`.`id` AS `article.id`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[757] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getArticleIdsByArticleIds\n[301] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` LEFT JOIN `yzfp0_fields` AS `field-dms3-shares` ON `field-dms3-shares`.`name` = 'dms3-shares' AND `field-dms3-shares`.`state` = 1 AND `field-dms3-shares`.`context` = 'com_content.article' LEFT JOIN `yzfp0_fields_values` AS `field_value-dms3-shares` ON `field_value-dms3-shares`.`field_id` = `field-dms3-shares`.`id` AND `field_value-dms3-shares`.`item_id` = article.id WHERE `article`.`id` IN (1259,3,4,5,6,7,8,9,10,11,12,13,15,16,21,22,23,31,36,37,1288,1287,1286,1279,1278,1277,1276,1303,261,1315,260,753,1053,1272,242,241,240,239,230,229,228,227,226,225,214,213,212,211,210,1309,1310,1311,1314,1322,1323,1324,1331,1332,1335,1298,1297,1293,1292,1291,1290,1265,1264,1263,1262,1258,1257,1256,1255,1251,1244,1234,1230,1229,1227,1224,1223,1222,1220,1214,1212,1211,1210,1209,1208,1207,1206,1205,1204,1199,1195,1190,1185,1184,1179,1178,1174,1165,1164,1163,1159,1158,1157,1156,1154,1153,1152,1151,1149,1148,1147,1144,1139,1138,1137,1135,1123,1119,1118,1117,1116,1115,1113,1107,1105,1104,1098,1097,1096,1095,1094,1091,1084,1083,1082,1081,1076,1075,1074,1073,1072,1066,1065,1060,1057,1052,1047,1046,1045,1044,1043,1037,1033,1032,1031,1027,1025,1024,1022,1020,1019,1016,1012,1010,1008,1007,1004,1003,1000,995,992,984,979,977,976,975,974,973,972,971,970,969,968,967,966,965,964,963,962,961,949,938,935,934,933,927,926,925,923,919,918,917,916,914,908,906,905,904,903,899,897,892,890,884,883,882,881,880,878,877,873,862,861,860,857,856,852,850,849,848,838,837,836,835,833,831,830,829,828,823,821,805,804,803,801,800,799,798,797,793,792,791,790,789,780,779,778,767,55,755,754,752,751,750,749,748,747,746,744,743,742,741,737,735,734,731,729,723,719,718,717,712,711,710,708,707,706,704,689,686,685,683,676,675,672,671,666,665,664,649,648,647,643,642,637,634,633,629,628,622,621,614,613,608,605,604,603,602,561,560,556,547,543,542,540,535,528,520,519,518,509,508,506,505,503,502,484,483,482,479,477,476,460,459,458,457,455,454,453,452,450,433,432,431,430,429,423,422,421,420,413,412,411,410,403,402,401,399,385,384,383,382,381,376,375,374,373,372,371,370,369,361,360,359,358,356,354,353,352,351,350,276,275,274,273,272,271,270,264,54,59,60,253,345,344,339,333,332,331,322,321,320,319,318,317,316,315,314,308,307,305,300,299,298,287,286,285,587,584,572,183,182,181,178,177,175,171,170,169,164,163,161,1261,847,846,1317,1260,663,607,570,569,567,566,565,564,563,562,493,492,491,438,437,436,435,434,283,258,256,255,254,184,174,173,172,166,165,160,159,158,149,148,147,139,138,137,136,134,133,132,131,130,124,121,119,116,115,113,2586,2589,2590,2591,2592,2594,2595,2596,2598,2599,2600,2605,2611) ORDER BY `field_value-dms3-shares`.`value` IS NULL, CAST(`field_value-dms3-shares`.`value` AS CHAR(1)) = '', CAST(`field_value-dms3-shares`.`value` AS CHAR(10)) = '0000-00-00', CAST(`field_value-dms3-shares`.`value` AS SIGNED INTEGER) = 0, CAST(`field_value-dms3-shares`.`value` AS SIGNED INTEGER) DESC, `field_value-dms3-shares`.`value` DESC LIMIT 3428ms944B/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,`article`.`title` AS `article.title`,`article`.`alias` AS `article.alias`,`article`.`catid` AS `article.catid`,`article`.`language` AS `article.language`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[765] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` IN (543,1314,354) ORDER BY FIELD(article.id,543,1314,354)263μs1.16KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `yzfp0_categories` AS `s` INNER JOIN `yzfp0_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`446μs5.22KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `yzfp0_categories` AS `s` INNER JOIN `yzfp0_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`341μs5.23KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `yzfp0_content` AS `a` INNER JOIN `yzfp0_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `yzfp0_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `yzfp0_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `yzfp0_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `yzfp0_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)625μs96.73KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT `article`.`id` AS `article.id`,`article`.`title` AS `article.title`,`article`.`alias` AS `article.alias`,`article`.`catid` AS `article.catid`,`article`.`language` AS `article.language`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[846] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` = 253 ORDER BY `article`.`title` IS NULL, CAST(`article`.`title` AS CHAR(1)) = '', CAST(`article`.`title` AS CHAR(10)) = '0000-00-00', CAST(`article`.`title` AS SIGNED INTEGER) = 0, CAST(`article`.`title` AS SIGNED INTEGER) ASC, `article`.`title` ASC LIMIT 1218μs1.13KB/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT `article`.`id` AS `article.id`,`article`.`hits` AS `article.hits`,'https://recintervcardiol.org/es/cardiopatia-isquemica/diferencias-relacionadas-con-el-sexo-en-pacientes-con-iamcest-analisis-por-puntuacion-de-propension\n[846] RegularLabs.Plugin.System.ArticlesAnywhere.Articles.getValuesByArticleIds\n[828] RegularLabs.Plugin.System.ArticlesAnywhere.Database.getResults\n[103] RegularLabs.Plugin.System.ArticlesAnywhere.Helpers.DB.__callStatic' as 'query_comment' FROM `yzfp0_content` AS `article` WHERE `article`.`id` = 253 ORDER BY `article`.`title` IS NULL, CAST(`article`.`title` AS CHAR(1)) = '', CAST(`article`.`title` AS CHAR(10)) = '0000-00-00', CAST(`article`.`title` AS SIGNED INTEGER) = 0, CAST(`article`.`title` AS SIGNED INTEGER) ASC, `article`.`title` ASC LIMIT 1185μs976B/plugins/system/articlesanywhere/src/Database.php:123Copy
  • SELECT * FROM `yzfp0_schemaorg` WHERE `itemId` = :itemId AND `context` = :context222μs1.86KBParams/plugins/system/schemaorg/src/Extension/Schemaorg.php:411Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `yzfp0_content` AS `a` INNER JOIN `yzfp0_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `yzfp0_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `yzfp0_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `yzfp0_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `yzfp0_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)466μs96.73KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `yzfp0_scheduler_tasks` AS `a` WHERE `a`.`state` = 1225μs1.68KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:466Copy
  • SELECT r.* FROM yzfp0_rereplacer AS r WHERE r.published = 1 AND (r.area = 'head' OR r.params LIKE '%\"use_xml\":\"1\"%') ORDER BY r.ordering, r.id421μs2.14KB/plugins/system/rereplacer/src/Items.php:97Copy
  • SELECT m.condition_id,m.item_id FROM yzfp0_conditions_map as m LEFT JOIN yzfp0_conditions as c ON c.id = m.condition_id WHERE `m`.`extension` = 'com_rereplacer' AND `c`.`published` = 1238μs896B/administrator/components/com_conditions/src/Model/ItemModel.php:815Copy
  • SELECT r.* FROM yzfp0_rereplacer AS r WHERE r.published = 1 AND (r.area = 'body' OR r.params LIKE '%\"use_xml\":\"1\"%') ORDER BY r.ordering, r.id407μs18.42KB/plugins/system/rereplacer/src/Items.php:97Copy
  • SELECT `value` FROM `yzfp0_fields_values` WHERE `item_id` = '253' AND `field_id` = 30404μs840B/tmp/regularlabs/custom_php/15263_af27ee991d0d77889539c6cba39057bf:36Copy
  • SELECT `value` FROM `yzfp0_fields_values` WHERE `item_id` = '253' AND `field_id` = 19193μs840B/tmp/regularlabs/custom_php/15263_af27ee991d0d77889539c6cba39057bf:61Copy
  • SELECT a.id,a.asset_id,a.title,a.alias,a.introtext,a.fulltext,a.state,a.catid,a.created,a.created_by,a.created_by_alias,CASE WHEN a.modified = '0000-00-00 00:00:00' THEN a.created ELSE a.modified END as modified,a.modified_by,a.checked_out,a.checked_out_time,a.publish_up,a.publish_down,a.images,a.urls,a.attribs,a.version,a.ordering,a.metakey,a.metadesc,a.access,a.hits,a.metadata,a.featured,a.language,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`lft` AS `category_lft`,`c`.`lft` AS `category_ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,ROUND(v.rating_sum / v.rating_count, 0) AS rating,`v`.`rating_count` AS `rating_count` FROM `yzfp0_content` AS `a` INNER JOIN `yzfp0_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `yzfp0_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `yzfp0_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `yzfp0_content_rating` AS `v` ON `v`.`content_id` = `a`.`id` WHERE `a`.`id` = 253 AND `c`.`published` > 0 AND (`a`.`state` = 1 AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= '2024-11-24 18:12:59') AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` = '0000-00-00 00:00:00' OR `a`.`publish_down` > '2024-11-24 18:12:59'))474μs95.44KB/libraries/regularlabs/src/Article.php:94Copy
  • SELECT `value` FROM `yzfp0_fields_values` WHERE `field_id` = 18 AND `item_id` = 2531.77ms856B/tmp/regularlabs/custom_php/15263_20d16d1e6db57666571c51c2623628e6:28Copy
  • SELECT COUNT(*) FROM `yzfp0_contentitem_tag_map` WHERE `type_alias` = 'com_content.article' AND `content_item_id` = 253336μs856B/tmp/regularlabs/custom_php/15263_2242f97af332d54d4fb204c150bc00a4:36Copy
  • SELECT r.* FROM yzfp0_rereplacer AS r WHERE r.published = 1 AND (r.area = 'everywhere' OR r.params LIKE '%\"use_xml\":\"1\"%') ORDER BY r.ordering, r.id347μs2.19KB/plugins/system/rereplacer/src/Items.php:97Copy
  • SELECT `session_id` FROM `yzfp0_session` WHERE `session_id` = ?203μs1.63KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:277Copy
  • UPDATE `yzfp0_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?509μs912BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:301Copy
  • infoplg_system_j2xml - plgSystemJ2xml::__construct
  • infoplg_system_basicauth - plgSystemBasicauth::__construct
  • infoplg_system_basicauth - PHP_SAPI: fpm-fcgi
  • infoplg_system_basicauth - authorization:
  • infoplg_system_basicauth - plgSystemBasicauth::onAfterRoute
  • infoplg_system_j2xml - plgSystemJ2xml::onAfterDispatch
  • infoplg_system_basicauth - plgSystemBasicauth::onBeforeRender